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This is a removing agent of biofilm periodontal pathogens containing a macrolide antibiotic having a 14-membered ring, preferably belonging to an erythromycin, a clarithromycin, a triacetyloleandomycin or a roxithromycin. Novel mutation in 23s rrna that confers low-level resostance to clarithromycin in helicobacter pylori window. Three of the strains also exhibited clarithromycin resistance.
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